Elevated HIV Infection of CD4 T Cells in MRKAd5 Vaccine Recipients Due to CD8 T Cells Targeting Adapted Epitopes-Reference-Cited by-同舟云学术

Elevated HIV Infection of CD4 T Cells in MRKAd5 Vaccine Recipients Due to CD8 T Cells Targeting Adapted Epitopes

Published:2021-07-26 Issue:16 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Qin Kai¹^ORCID,Boppana Sushma¹^ORCID,Carlson Jonathan M.²,Fiore-Gartland Andrew³^ORCID,Files Jacob¹,Zeng Jie¹,Edberg Jeffrey¹,Mailliard Robbie B.⁴,Ochsenbauer Christina¹,Bansal Anju¹^ORCID,Goepfert Paul¹^ORCID

Affiliation:

1. Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA

2. Microsoft Research, Redmond, Washington, USA

3. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

4. Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Abstract

Despite the well-established contribution of CD8 T cells in HIV control, prior CD8 T cell-based HIV vaccines have failed to demonstrate any efficacy in preventing viral infection. One such vaccine, known as the MRKAd5 vaccine, showed a potential increased risk of viral infection among vaccine recipients.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00160-21

Reference47 articles.

1. Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

2. Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial

3. Dramatic Rise in Plasma Viremia after CD8+ T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques

4. Cytotoxic Capacity of SIV-Specific CD8+ T Cells against Primary Autologous Targets Correlates with Immune Control in SIV-Infected Rhesus Macaques

5. CD8 + Lymphocytes Are Required for Maintaining Viral Suppression in SIV-Infected Macaques Treated with Short-Term Antiretroviral Therapy

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