Inactivated SARS-CoV-2 Vaccine Shows Cross-Protection against Bat SARS-Related Coronaviruses in Human ACE2 Transgenic Mice-Reference-Cited by-同舟云学术

Inactivated SARS-CoV-2 Vaccine Shows Cross-Protection against Bat SARS-Related Coronaviruses in Human ACE2 Transgenic Mice

Published:2022-04-27 Issue:8 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Liu Mei-Qin¹²,Jiang Ren-Di¹²,Guo Jing³,Chen Ying¹²,Yang Dong-Sheng³,Wang Xi¹²,Lin Hao-Feng¹²,Li Ang¹²,Li Bei¹,Hu Ben¹,Wang Ze-Jun³,Yang Xing-Lou¹,Shi Zheng-Li¹^ORCID

Affiliation:

1. Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China

2. University of Chinese Academy of Sciences, Beijing, China

3. Wuhan Institute of Biological Products Co. Ltd., Jiangxia District, Wuhan, China

Abstract

The genetic diversity of SARSr-CoVs in wildlife and their potential risk of cross-species infection highlight the necessity of developing wide-spectrum vaccines against infection of various SARSr-CoVs. In this study, we tested the protective efficacy of the SARS-CoV-2 inactivated vaccine (IAV) against two SARSr-CoVs with different spike proteins in human ACE2 transgenic mice.

Funder

Key Program of Chinese Academy of Sciences

Youth innovation promotion association of CAS

Strategic Priority Research Program of the Chinese Academy of Sciences

China Natural Science Foundation

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00169-22

Reference46 articles.