Epstein-Barr virus-encoded small RNAs (EBERs) do not modulate interferon effects in infected lymphocytes-Reference-Cited by-同舟云学术

Epstein-Barr virus-encoded small RNAs (EBERs) do not modulate interferon effects in infected lymphocytes

Published:1992-08 Issue:8 Volume:66 Page:5133-5136
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Swaminathan S¹,Huneycutt B S¹,Reiss C S¹,Kieff E¹

Affiliation:

1. Department of Medicine, Harvard University, Brigham and Women's Hospital, Boston, Massachusetts 02115.

Abstract

The recent derivation of otherwise isogenic Epstein-Barr virus (EBV) recombinants carrying or lacking the EBV small RNA (EBER) genes enabled us to test whether EBERs are similar to adenovirus VA RNAs in modulating interferon (IFN) effects on virus infection. EBER-positive and -negative EBV recombinants did not differ in their sensitivity to alpha interferon (IFN-alpha)- or IFN-gamma-mediated inhibition of lymphocyte growth transformation. In addition, EBERs did not decrease the inhibitory effects of IFN on vesicular stomatitis virus replication in EBV-transformed lymphocytes. EBER deletion also did not render EBV-transformed B lymphocytes susceptible to an IFN effect on cell proliferation or EBV replication.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.66.8.5133-5136.1992

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