Population Pharmacokinetics of Mefloquine Intermittent Preventive Treatment for Malaria in Pregnancy in Gabon-Reference-Cited by-同舟云学术

Population Pharmacokinetics of Mefloquine Intermittent Preventive Treatment for Malaria in Pregnancy in Gabon

Published:2019-02 Issue:2 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ramharter Michael¹²³,Schwab Matthias⁴⁵,Mombo-Ngoma Ghyslain¹²³⁶,Zoleko Manego Rella¹²³⁷,Akerey-Diop Daisy¹²,Basra Arti¹²,Mackanga Jean-Rodolphe¹²,Würbel Heike¹²,Wojtyniak Jan-Georg⁴⁸,Gonzalez Raquel⁹,Hofmann Ute⁴⁵,Geditz Mirjam⁴⁵,Matsiegui Pierre-Blaise⁷,Kremsner Peter G.¹²,Menendez Clara⁹,Kerb Reinhold⁴⁵,Lehr Thorsten⁸

Affiliation:

1. Centre de Recherches Médicales de Lambaréné, Albert Schweitzer Hospital, Lambaréné, Gabon

2. Institut für Tropenmedizin, Universität Tübingen, Tübingen, Germany

3. Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine University Medical Center Hamburg-Eppendorf, Hamburg, Germany

4. Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany

5. Department of Clinical Pharmacology, University Hospital, Tübingen, Germany

6. Département de Parasitologie, Université des Sciences de la Santé, Libreville, Gabon

7. Ngounié Medical Research Centre, Fougamou, Gabon

8. Clinical Pharmacy, Saarland University, Saarbrücken, Germany

9. Barcelona Centre for International Health Research (CRESIB, Hospital Clínic—Universitat de Barcelona), Barcelona, Spain

Abstract

Mefloquine was evaluated as an alternative for intermittent preventive treatment of malaria in pregnancy (IPTp) due to increasing resistance against the first-line drug sulfadoxine-pyrimethamine (SP). This study determined the pharmacokinetic characteristics of the mefloquine stereoisomers and the metabolite carboxymefloquine (CMQ) when given as IPTp in pregnant women.

Funder

Liverpool School of Tropical Medicine

European Commission Horizon 2020 UPGx

Deutsche Forschungsgemeinschaft

Bundesministerium für Bildung und Forschung

European and Developing Countries Clinical Trials Partnership

Robert Bosch Stiftung

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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