Population Pharmacokinetic Model and Optimal Sampling Strategies for Micafungin in Critically Ill Patients Diagnosed with Invasive Candidiasis

Author:

Boonstra J. M.1,van der Elst K. C.1,Zijlstra J. G.2,van der Werf T. S.34,Alffenaar J. W. C.567ORCID,Touw D. J.18

Affiliation:

1. University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology, Groningen, the Netherlands

2. University of Groningen, University Medical Center Groningen, Department of Critical Care, Groningen, the Netherlands

3. University of Groningen, University Medical Center Groningen, Department of Internal Medicine, Groningen, the Netherlands

4. University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases and Tuberculosis, Groningen, the Netherlands

5. The University of Sydney, Faculty of Medicine and Health, School of Pharmacy, Sydney, New South Wales, Australia

6. Westmead hospital, Sydney, New South Wales, Australia

7. Sydney Institute for Infectious Diseases, University of Sydney, Sydney, New South Wales, Australia

8. University of Groningen, Groningen Research Institute of Pharmacy, Department of Pharmaceutical Analysis, Groningen, the Netherlands

Abstract

Candida bloodstream infections are associated with high attributable mortality, where early initiation of adequate antifungal therapy is important to increase survival in critically ill patients. The exposure variability of micafungin, a first-line agent used for the treatment of invasive candidiasis, in critically ill patients is significant, potentially resulting in underexposure in a substantial portion of these patients.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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