Antimicrobial Activity of 8-Quinolinols, Salicylic Acids, Hydroxynaphthoic Acids, and Salts of Selected Quinolinols with Selected Hydroxy-Acids

Author:

Gershon Herman1,Parmegiani Raulo1

Affiliation:

1. Pfister Chemical Works, Ridgefield, New Jersey

Abstract

Seventy-seven compounds were screened by the disc-plate method against strains of five bacteria and five fungi. A new constant was proposed to describe the antimicrobial activity of a compound in a defined system of organisms. This constant includes not only the inhibitory level of activity of the material but also the number of organisms inhibited. This constant, the antimicrobial spectrum index, was compared with the antimicrobial index of Albert.

Publisher

American Society for Microbiology

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference5 articles.

1. ALBERT A. 1960. Selective toxicity 2nd ed. Methuen & Co. Ltd. London.

2. Process for the preparation of neutral salts of o-oxyquinoline with polybasic inorganic or with organic acids;Co E, F.;Ger. Patent,1907

3. -1956. Oxine and its derivatives;D, R. G.;Parts,1954

4. MERCK & Co. INC. 1960. Merck Index 7th ed. Rahway N.J.

5. MOREL A. A. ROCHAIX L. PERROT ANI) A. PEGON. 1936. Antiseptic power of some more derivatives of 8-hydroxyquinoline for various pathogenic bacteria. Compt. rend. soc. biol. 122:1115-1116.

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