Affiliation:
1. Department of Food Technology and Biochemical Engineering, Jadavpur University, Calcutta-32, India
Abstract
The use of a washed-cell system to study the factors controlling the synthesis of alkaline phosphatase and neomycin by
Streptomyces fradiae
has shown that calcium and magnesium salts are stimulatory, with maximal synthesis of both achieved with a combination of these salts. Among all the carbon sources studied, only arabinose induces alkaline phosphatase synthesis, whereas glucose and other carbon sources inhibit the synthesis of the enzyme. Asparagine is a very good inducer of enzyme and neomycin synthesis, with lysine and alanine having lower stimulatory effects. The appearance of alkaline phosphatase is due to de novo protein synthesis as demonstrated by the inhibition of its synthesis in the presence of chloramphenicol. There is a good correlation between the synthesis of alkaline phosphatase and neomycin biosynthesis.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
14 articles.
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