Pharyngeal Microbial Signatures Are Predictive of the Risk of Fungal Pneumonia in Hematologic Patients-Reference-Cited by-同舟云学术

Pharyngeal Microbial Signatures Are Predictive of the Risk of Fungal Pneumonia in Hematologic Patients

Published:2021-07-15 Issue:8 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Costantini Claudio¹,Nunzi Emilia¹²,Spolzino Angelica³,Palmieri Melissa¹,Renga Giorgia¹,Zelante Teresa¹,Englmaier Lukas⁴,Coufalikova Katerina⁴,Spáčil Zdeněk⁴,Borghi Monica¹,Bellet Marina M.¹,Acerbi Enzo⁵,Puccetti Matteo⁶,Giovagnoli Stefano⁶,Spaccapelo Roberta¹²,Talesa Vincenzo N.¹²,Lomurno Giuseppe¹,Merli Francesco⁷,Facchini Luca⁷,Spadea Antonio⁸,Melillo Lorella⁹,Codeluppi Katia⁷,Marchesi Francesco⁸,Marchesini Gessica¹⁰,Valente Daniela⁹,Dragonetti Giulia¹¹,Nadali Gianpaolo¹⁰,Pagano Livio¹¹¹²,Aversa Franco³,Romani Luigina¹²^ORCID

Affiliation:

1. Department of Medicine and Surgery, University of Perugia, Perugia, Italy

2. University Research Center on Functional Genomics (C.U.R.Ge.F), University of Perugia, Perugia, Italy

3. Haematology and Bone Marrow Transplant Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy

4. RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic

5. Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore

6. Department of Pharmaceutical Science, University of Perugia, Perugia, Italy

7. Hematology, AUSL-IRCCS, Reggio Emilia, Italy

8. Hematology and Stem Cell Transplant Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy

9. Hematology, S. Giovanni Rotondo Hospital, San Giovanni Rotondo, Italy

10. Hematology, University of Verona, Verona, Italy

11. Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Rome, Italy

12. Istituto di Ematologia, Università Cattolica del Sacro Cuore, Rome, Italy

Abstract

The ability to predict invasive fungal infections (IFI) in patients with hematological malignancies is fundamental for successful therapy. Although gut dysbiosis is known to occur in hematological patients, whether airway dysbiosis also contributes to the risk of IFI has not been investigated.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00105-21

Reference57 articles.

1. Attributable Hospital Cost and Antifungal Treatment of Invasive Fungal Diseases in High-Risk Hematology Patients: an Economic Modeling Approach

2. Hidden Killers: Human Fungal Infections

3. Risk stratification for invasive fungal infections in patients with hematological malignancies: SEIFEM recommendations

4. Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosis

5. A Risk Prediction Score for Invasive Mold Disease in Patients with Hematological Malignancies

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