Salmonella enterica Serovar Typhimurium Interacts with CD209 Receptors To Promote Host Dissemination and Infection

Author:

Ye Chenglin1,Li Qiao1,Li Xinyi2,Park Chae Gyu3,He Yingxia1,Zhang Yingmiao1,Wu Bicong1,Xue Ying1,Yang Kun4,Lv Yin1,Ying Xiao-Ling1,Ding Hong-Hui1,Cai Huahua1,Alkraiem Ayman Ahmad15,Njiri Olivia1,Tembo John1,Huang Hong-Ping1,Li An-Yi1,Gong Jianping1,Qin Jichao1,Cheng Bing1,Wei Xiang1,Sun Ziyong1,Zhang Shu-Sheng6,Zhang Pei6,Zheng Guo-Xing6,Li Wei7ORCID,Kan Biao7,Yan Meiying7,Xiding Xiamu8,Huo Xixiang9,Zeng Yingchun9,Peng Hua10,Fu Yangxin11,Klena John D.12,Skurnik Mikael13ORCID,Jiang Ling-Yu1,Chen Tie1

Affiliation:

1. Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, Hubei, China

2. Department of Clinical Laboratory, Jingmen No. 1 People’s Hospital, Jingmen, China

3. Laboratory of Immunology, Brain Korea 21 PLUS Project for Medical Science, Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea

4. Department of Pathogen Biology and Immunology, Shihezi University School of Medicine, Shihezi, Xinjiang, China

5. Department of Biology, College of Science, Taibah University, Medina, Kingdom of Saudi Arabia

6. Department of Biomedical Science, College of Medicine-Rockford, University of Illinois at Chicago, Rockford, Illinois, USA

7. Department of Diarrheal Diseases, National Institute for Communicable Diseases Control and Prevention, Beijing, China

8. Division of Disease Control and Prevention for Endemic Diseases, Wenquan Center for Disease Control and Prevention, Xinjiang, China

9. Hubei Provincial Center for Disease Control and Prevention (CDC), Wuhan, Hubei, China

10. Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

11. Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

12. Centers for Disease Control and Prevention, Atlanta, Georgia, USA

13. Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland

Abstract

Salmonella enterica serovar Typhimurium, a Gram-negative bacterium, can cause infectious diseases ranging from gastroenteritis to systemic dissemination and infection. However, the molecular mechanisms underlying this bacterial dissemination have yet to be elucidated. A study indicated that using the lipopolysaccharide (LPS) core as a ligand, S .

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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