Repurposing of MitoTam: Novel Anti-Cancer Drug Candidate Exhibits Potent Activity against Major Protozoan and Fungal Pathogens-Reference-Cited by-同舟云学术

Repurposing of MitoTam: Novel Anti-Cancer Drug Candidate Exhibits Potent Activity against Major Protozoan and Fungal Pathogens

Published:2022-08-16 Issue:8 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Arbon Dominik¹,Ženíšková Kateřina¹,Šubrtová Karolína¹,Mach Jan¹,Štursa Jan²,Machado Marta³,Zahedifard Farnaz¹,Leštinová Tereza⁴,Hierro-Yap Carolina⁵,Neuzil Jiri²⁶⁷,Volf Petr⁴,Ganter Markus⁸,Zoltner Martin¹,Zíková Alena⁵⁹,Werner Lukáš²,Sutak Robert¹^ORCID

Affiliation:

1. Department of Parasitology, Faculty of Science, Charles University, BIOCEV, Vestec, Czech Republic

2. Institute of Biotechnology, Czech Academy of Sciences, BIOCEV, Vestec, Czech Republic

3. Graduate Program in Areas of Basic and Applied Biology, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Portugal

4. Faculty of Sciences, Charles University, Department of Parasitology, Prague, Czech Republic

5. Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic

6. School of Pharmacy and Medical Science, Griffith University, Southport, Queensland, Australia

7. Department of Physiology, Faculty of Science, Charles University, Prague, Czech Republic

8. Centre for Infectious Diseases, Parasitology, Heidelberg University Hospital, Heidelberg, Germany

9. Faculty of Science, University of South Bohemia, České Budějovice, Czech Republic

Abstract

Many of the currently available anti-parasitic and anti-fungal frontline drugs have severe limitations, including adverse side effects, complex administration, and increasing occurrence of resistance. The discovery and development of new therapeutic agents is a costly and lengthy process.

Funder

Grantová Agentura České Republiky

The European Regional Development Fund and Ministry of Education, Youth and Sports of the Czech Republic

Grantová Agentura, Univerzita Karlova

Fundacio para a Ciencia e Tecnologia

Deutsche Forschungsgemeinschaft

Baden-Württemberg Stiftung

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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