Associations between Aminoquinoline Resistance Genotypes and Clinical Presentations of Plasmodium falciparum Infection in Uganda-Reference-Cited by-同舟云学术

Associations between Aminoquinoline Resistance Genotypes and Clinical Presentations of Plasmodium falciparum Infection in Uganda

Published:2020-09-21 Issue:10 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Cuu Gloria¹,Asua Victor¹^ORCID,Tukwasibwe Stephen¹,Nsobya Sam L.¹²,Nanteza Ann³,Kimuda Magambo Phillip³,Mpimbaza Arthur¹⁴,Rosenthal Philip J.⁵^ORCID

Affiliation:

1. Infectious Diseases Research Collaboration, Kampala, Uganda

2. Department of Pathology, College of Health Science, Makerere University, Kampala, Uganda

3. College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, Kampala, Uganda

4. Child Health and Development Centre, Makerere University College of Health Sciences, Kampala, Uganda

5. Department of Medicine, University of California, San Francisco, California, USA

Abstract

Mutations that mediate resistance of Plasmodium falciparum to aminoquinoline antimalarials are selected by prior drug use and may alter parasite fitness, but associations with clinical presentations are uncertain. We evaluated genotypes in samples from a case-control study of determinants of severe malaria in Ugandan children 4 months to 10 years of age. We studied 274 cases with severe malaria matched by age and geography to 275 uncomplicated malaria controls and 179 asymptomatic parasitemic controls.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00721-20

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