The Protease SplB of Staphylococcus aureus Targets Host Complement Components and Inhibits Complement-Mediated Bacterial Opsonophagocytosis-Reference-Cited by-同舟云学术

The Protease SplB of Staphylococcus aureus Targets Host Complement Components and Inhibits Complement-Mediated Bacterial Opsonophagocytosis

Published:2022-01-18 Issue:1 Volume:204 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Dasari Prasad¹,Nordengrün Maria²,Vilhena Cláudia¹,Steil Leif³,Abdurrahman Goran²,Surmann Kristin³,Dhople Vishnu³,Lahrberg Julia²,Bachert Claus⁴,Skerka Christine¹,Völker Uwe³,Bröker Barbara M.²,Zipfel Peter F.¹⁵^ORCID

Affiliation:

1. Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany

2. Institute of Immunology, University Medicine Greifswald, Greifswald, Germany

3. Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany

4. Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium

5. Institute of Microbiology, Friedrich Schiller University, Jena, Germany

Abstract

The success of bacterial pathogens in immunocompetent humans depends on the control and inactivation of host immunity. S. aureus , like many other pathogens, efficiently blocks host complement attack early in infection. Aiming to understand the role of the S. aureus -encoded orphan proteases SplA to SplD, we asked whether these proteins play a role in immune escape.

Funder

State of Mecklenburg Western Pomerania

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00184-21

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