Butyrate Differentiates Permissiveness to Clostridioides difficile Infection and Influences Growth of Diverse C. difficile Isolates

Author:

Pensinger Daniel A.12,Fisher Andrea T.3,Dobrila Horia A.124,Van Treuren William3,Gardner Jackson O.3,Higginbottom Steven K.3,Carter Matthew M.3,Schumann Benjamin5,Bertozzi Carolyn R.56,Anikst Victoria7,Martin Cody48,Robilotti Elizabeth V.9,Chow Jo May10,Buck Rachael H.10,Tompkins Lucy S.9,Sonnenburg Justin L.311ORCID,Hryckowian Andrew J.12ORCID

Affiliation:

1. Department of Medicine, Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA

2. Department of Medical Microbiology & Immunology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA

3. Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, California, USA

4. Microbiology Doctoral Training Program, University of Wisconsin—Madison, Madison, Wisconsin, USA

5. Department of Chemistry, Stanford University, Stanford, California, USA

6. Howard Hughes Medical Institute, Stanford University, Stanford, California, USA

7. Department of Pathology, Stanford University School of Medicine, Stanford, California, USA

8. Department of Bacteriology, University of Wisconsin—Madison, Madison, Wisconsin, USA

9. Department of Medicine, Division of Infectious Disease, Stanford University School of Medicine, Stanford, California, USA

10. Abbott, Nutrition Division, Columbus, Ohio, USA

11. Chan Zuckerberg BioHub, San Francisco, California, USA

Abstract

Clostridioides difficile is a leading cause of infectious diarrhea in humans, and it imposes a tremendous burden on the health care system. Current treatments for C. difficile infection (CDI) include antibiotics and fecal microbiota transplant, which contribute to recurrent CDIs and face major regulatory hurdles, respectively.

Funder

Abbott | Abbott Nutrition

HHS | National Institutes of Health

Stanford University

Alexander von Humboldt Foundation

Howard Hughes Medical Institute

University of Wisconsin-Madison

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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