Identification of Mutations Related to Streptomycin Resistance in Clinical Isolates of Mycobacterium tuberculosis and Possible Involvement of Efflux Mechanism-Reference-Cited by-同舟云学术

Identification of Mutations Related to Streptomycin Resistance in Clinical Isolates of Mycobacterium tuberculosis and Possible Involvement of Efflux Mechanism

Published:2008-08 Issue:8 Volume:52 Page:2947-2949
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Spies Fernanda S.¹²,Almeida da Silva Pedro E.³,Ribeiro Marta O.²,Rossetti Maria Lucia²⁴,Zaha Arnaldo¹⁵

Affiliation:

1. Programa de Pós-graduação em Genética e Biologia Molecular, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

2. Fundação Estadual de Produção e Pesquisa em Saúde do Estado do Rio Grande do Sul, Porto Alegre, Brazil

3. Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Rio Grande, Campus da Saúde, Rio Grande, Brazil

4. Programa de Pós-graduação em Ciências em Genética e Toxicologia Aplicada-Universidade Luterana do Brasil, Canoas, Brazil

5. Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

Abstract

ABSTRACT The MIC for streptomycin in the presence of efflux pump (EP) inhibitors and the sequencing of rpsL , rrs , and gidB genes provided evidence for the possible participation of EP in low-level streptomycin (STR) resistance of some isolates without mutations. Mutation in the gidB gene and an EP could act synergistically to confer low STR resistance.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01570-07

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