Co-occurrence of Plasmid-Mediated Tigecycline and Carbapenem Resistance in Acinetobacter spp. from Waterfowls and Their Neighboring Environment-Reference-Cited by-同舟云学术

Co-occurrence of Plasmid-Mediated Tigecycline and Carbapenem Resistance in Acinetobacter spp. from Waterfowls and Their Neighboring Environment

Published:2020-04-21 Issue:5 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Cui Chao-Yue¹²,Chen Chong¹²,Liu Bao-Tao³,He Qian¹²,Wu Xiao-Ting¹²,Sun Ruan-Yang¹²,Zhang Yan¹²,Cui Ze-Hua¹²,Guo Wen-Ying¹²,Jia Qiu-lin¹²,Li Cang¹²,Kreiswirth Barry N.⁴,Liao Xiao-Ping¹²⁵,Chen Liang⁴,Liu Ya-Hong¹²⁵,Sun Jian¹²⁵^ORCID

Affiliation:

1. National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, China

2. Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, Guangdong, China

3. College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, China

4. Hackensack-Meridian Health Center for Discovery and Innovation, Nutley, New Jersey, USA

5. Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, China

Abstract

Tigecycline serves as one of the antibiotics of last resort to treat multidrug-resistant (including carbapenem-resistant) pathogens. However, the recently emerged plasmid-mediated tigecycline resistance mechanism, Tet(X), challenges the clinical efficacy of this class of antibiotics. In this study, we detected 180 tet (X)-harboring Acinetobacter isolates (8.9%, n = 180) from 2,018 samples collected from avian farms and adjacent environments in China.

Funder

National Key Research and Development Program of China

Program for Innovative Research Team in the University of Ministry of Education of China

Foundation for Innovation and Strengthening School Project of Guangdong, China

Foundation for the National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02502-19

Reference40 articles.