DNA Alkylation Damage as a Sensor of Nitrosative Stress in Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

DNA Alkylation Damage as a Sensor of Nitrosative Stress in Mycobacterium tuberculosis

Published:2003-02 Issue:2 Volume:71 Page:997-1000
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Durbach Steven I.¹,Springer Burkhard²,Machowski Edith E.¹,North Robert J.³,Papavinasasundaram K. G.⁴,Colston M. Jo⁴,Böttger Erik C.²,Mizrahi Valerie¹

Affiliation:

1. MRC/NHLS/WITS Molecular Mycobacteriology Research Unit, School of Pathology, University of the Witwatersrand, and National Health Laboratory Service, Johannesburg, South Africa

2. Institute für Medizinische Mikrobiologie, Universität Zürich, Zürich, Switzerland

3. Trudeau Medical Institute, Saranac Lake, New York

4. Division of Mycobacterial Research, National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom

Abstract

ABSTRACT One of the cellular consequences of nitrosative stress is alkylation damage to DNA. To assess whether nitrosative stress is registered on the genome of Mycobacterium tuberculosis , mutants lacking an alkylation damage repair and reversal operon were constructed. Although hypersensitive to the genotoxic effects of N -methyl- N ′-nitro- N -nitrosoguanidine in vitro, the mutants displayed no phenotype in vivo, suggesting that permeation of nitrosative stress to the level of cytotoxic DNA damage is restricted.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.71.2.997-1000.2003

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