Monoclonal Antibody to Fungal Glucosylceramide Protects Mice against Lethal Cryptococcus neoformans Infection-Reference-Cited by-同舟云学术

Monoclonal Antibody to Fungal Glucosylceramide Protects Mice against Lethal Cryptococcus neoformans Infection

Published:2007-10 Issue:10 Volume:14 Page:1372-1376
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Rodrigues Marcio L.¹,Shi Li²,Barreto-Bergter Eliana¹,Nimrichter Leonardo¹,Farias Sandra E.³,Rodrigues Elaine G.⁴,Travassos Luiz R.⁴,Nosanchuk Joshua D.²⁵

Affiliation:

1. Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil

2. Division of Infectious Diseases, Department of Medicine

3. Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

4. Disciplina de Biologia Celular, Universidade Federal de São Paulo, São Paulo SP 04023-062, Brazil

5. Department of Microbiology/Immunology, Albert Einstein College of Medicine, Bronx, New York 10461

Abstract

ABSTRACT Glucosylceramides (GlcCer) are involved in the regulation of Cryptococcus neoformans virulence. In the present study, we demonstrate that passive immunization with a monoclonal antibody to GlcCer significantly reduces host inflammation and prolongs the survival of mice lethally infected with C. neoformans , revealing a potential therapeutic strategy to control cryptococcosis.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.00202-07

Reference40 articles.

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5. Casadevall, A., E. Dadachova, and L. A. Pirofski. 2004. Passive antibody therapy for infectious diseases. Nat. Rev. Microbiol.2:695-703.

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