The Iron Efflux Protein Ferroportin Regulates the Intracellular Growth of Salmonella enterica-Reference-Cited by-同舟云学术

The Iron Efflux Protein Ferroportin Regulates the Intracellular Growth of Salmonella enterica

Published:2006-05 Issue:5 Volume:74 Page:3065-3067
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Chlosta Sabine¹²,Fishman Douglas S.³⁴,Harrington Lynne¹,Johnson Erin E.³,Knutson Mitchell D.⁵,Wessling-Resnick Marianne³,Cherayil Bobby J.¹

Affiliation:

1. Pediatric Gastroenterology Unit, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts;

2. Department of Medical Microbiology and Immunology of Infection, Charité Medical School, Berlin, Germany

3. Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts

4. Division of Pediatric Gastroenterology and Nutrition, Children's Hospital, Boston, Massachusetts

5. Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida

Abstract

ABSTRACT We investigated the influence of the macrophage iron exporter ferroportin and its ligand hepcidin on intracellular Salmonella growth. Elevated ferroportin expression inhibited bacterial multiplication; hepcidin-induced ferroportin down-regulation enhanced it. Expression analysis of iron-responsive Salmonella genes indicated ferroportin-mediated iron deprivation. These results demonstrate a role for ferroportin in antimicrobial resistance.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.74.5.3065-3067.2006

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