Antimicrobial Activities of Jadomycin B and Structurally Related Analogues-Reference-Cited by-同舟云学术

Antimicrobial Activities of Jadomycin B and Structurally Related Analogues

Published:2009-03 Issue:3 Volume:53 Page:1245-1247
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Jakeman David L.¹²,Bandi Srinivasulu¹³,Graham Cathy L.¹,Reid Taryn R.¹,Wentzell Jason R.¹,Douglas Susan E.³

Affiliation:

1. College of Pharmacy, Dalhousie University, 5968 College St., Halifax, Nova Scotia B3H 3J5, Canada

2. Department of Chemistry, Dalhousie University, Halifax, Nova Scotia B3H 4J3, Canada

3. Institute for Marine Biosciences, National Research Council of Canada, Halifax, Nova Scotia B3H 3Z1, Canada

Abstract

ABSTRACT Natural products are leads for new antibiotics as a result of their structural complexity and diversity. We have isolated a series of structurally related polyketide-derived natural products from Streptomyces venezuelae ISP5230. The most active of these jadomycin analogues showed good activity against a variety of staphylococci, including methicillin-resistant Staphylococcus aureus .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00801-08

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3. Doull, J. L., S. W. Ayer, A. K. Singh, and P. Thibault. 1993. Production of a novel polyketide antibiotic, jadomycin B, by Streptomyces venezuelae following heat shock. J. Antibiot.46:869-871.

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5. Jakeman, D. L., S. Farrell, W. Young, R. J. Doucet, and S. C. Timmons. 2005. Novel jadomycins: incorporation of non-natural and natural amino acids. Bioorg. Med. Chem. Lett.15:1447-1449.

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