Population Pharmacokinetic Study of Cefazolin Dosage Adaptation in Bacteremia and Infective Endocarditis Based on a Nomogram-Reference-Cited by-同舟云学术

Population Pharmacokinetic Study of Cefazolin Dosage Adaptation in Bacteremia and Infective Endocarditis Based on a Nomogram

Published:2019-10 Issue:10 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bellouard Ronan¹²^ORCID,Deschanvres Colin³⁴,Deslandes Guillaume¹,Dailly Éric¹²,Asseray Nathalie³⁴,Jolliet Pascale¹⁵,Boutoille David³⁴⁶,Gaborit Benjamin³⁴⁶,Grégoire Matthieu¹⁷^ORCID

Affiliation:

1. Clinical Pharmacology Department, Nantes University Hospital, Nantes, France

2. EE1701 Microbiotas, Hosts, Antibiotics and Bacterial Resistances, University of Nantes, Nantes, France

3. Infectious Diseases Department, Nantes University Hospital, Nantes, France

4. CIC 1413, INSERM, Nantes, France

5. UMR INSERM 1246 SPHERE Methods in Patients-Centered Outcomes and Health Research, University of Nantes, Nantes, France

6. EA 3826 Thérapeutiques Cliniques et Expérimentales des Infections, University of Nantes, Nantes, France

7. UMR INSERM 1235 The Enteric Nervous System in Gut and Brain Disorders, University of Nantes, Nantes, France

Abstract

Optimal dosing of continuous-infusion cefazolin can be challenging in patients being treated for bacteremia or infective endocarditis. The aim of this work is to describe and analyze the pharmacokinetics of cefazolin in those patients using a population pharmacokinetics modeling approach and to establish a nomogram to determine the optimal daily dose. Population pharmacokinetics were modeled using the Pmetrics package for R.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00806-19

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