Molecular Basis for Bordetella pertussis Interference with Complement, Coagulation, Fibrinolytic, and Contact Activation Systems: the Cryo-EM Structure of the Vag8-C1 Inhibitor Complex-Reference-Cited by-同舟云学术

Molecular Basis for Bordetella pertussis Interference with Complement, Coagulation, Fibrinolytic, and Contact Activation Systems: the Cryo-EM Structure of the Vag8-C1 Inhibitor Complex

Published:2021-04-27 Issue:2 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Dhillon Arun¹,Deme Justin C.¹²,Furlong Emily¹,Roem Dorina³,Jongerius Ilse³⁴,Johnson Steven¹,Lea Susan M.¹²^ORCID

Affiliation:

1. Sir William Dunn School of Pathology, Oxford, United Kingdom

2. Central Oxford Structural Molecular Imaging Centre, Oxford, United Kingdom

3. Sanquin Research, Department of Immunopathology, and Landsteiner Laboratory, Amsterdam University Medical Centre, Amsterdam Infection and Immunity Institute, Amsterdam, the Netherlands

4. Department of Pediatric Immunology, Rheumatology, and Infectious Diseases, Emma Children’s Hospital, Amsterdam University Medical Centre, Amsterdam, the Netherlands

Abstract

The structure of a 10-kDa protein complex is one of the smallest to be determined using cryo-electron microscopy at high resolution. The structure reveals that C1-INH is sequestered in an inactivated state by burial of the reactive center loop in Vag8.

Funder

Wellcome

UKRI | Medical Research Council

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02823-20

Reference48 articles.

1. Complement and its role in innate and adaptive immune responses

2. The plasma contact system, a protease cascade at the nexus of inflammation, coagulation and immunity