Colloidal Physics Modeling Reveals How Per-Ribosome Productivity Increases with Growth Rate in Escherichia coli-Reference-Cited by-同舟云学术

Colloidal Physics Modeling Reveals How Per-Ribosome Productivity Increases with Growth Rate in Escherichia coli

Published:2023-02-28 Issue:1 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Maheshwari Akshay J.¹^ORCID,Sunol Alp M.²^ORCID,Gonzalez Emma²^ORCID,Endy Drew¹^ORCID,Zia Roseanna N.²^ORCID

Affiliation:

1. Department of Bioengineering, Stanford University, Stanford, California, USA

2. Department of Chemical Engineering, Stanford University, Stanford, California, USA

Abstract

Ribosomes are the factories in cells that synthesize proteins. When cells grow faster, there are not enough ribosomes to keep up with the demand for faster protein synthesis without individual ribosomes becoming more productive.

Funder

Stanford Graduate Fellowship

DOC | National Institute of Standards and Technology

Foundation for the National Institutes of Health

National Science Foundation

SU | Stanford Bio-X

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02865-22

Reference44 articles.

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2. Molecular crowding limits translation and cell growth

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4. Escherichia coli ribosomes translate in vivo with variable rate.

5. Growth rate of polypeptide chains as a function of the cell growth rate in a mutant of Escherichia coli 15

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