SepA Enhances Shigella Invasion of Epithelial Cells by Degrading Alpha-1 Antitrypsin and Producing a Neutrophil Chemoattractant-Reference-Cited by-同舟云学术

SepA Enhances Shigella Invasion of Epithelial Cells by Degrading Alpha-1 Antitrypsin and Producing a Neutrophil Chemoattractant

Published:2021-12-21 Issue:6 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Meza-Segura Mario¹²,Birtley James R.³,Maldonado-Contreras Ana¹²,Mueller Christian⁴,Simin Karl J.⁵,Stern Lawrence J.³,McCormick Beth A.¹²

Affiliation:

1. Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA

2. Program in Microbiome Dynamics, University of Massachusetts Medical School, Worcester, Massachusetts, USA

3. Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

4. Horae Gene Therapy Center, University of Massachusetts Medical School, Worcester, Massachusetts, USA

5. Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

Abstract

Shigella is the second leading cause of diarrheal death globally. In this study, we identified the host protein targets of SepA, Shigella ’s major protein secreted in culture.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02833-21

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