The Protein Kinase A-Dependent Phosphoproteome of the Human Pathogen Aspergillus fumigatus Reveals Diverse Virulence-Associated Kinase Targets-Reference-Cited by-同舟云学术

The Protein Kinase A-Dependent Phosphoproteome of the Human Pathogen Aspergillus fumigatus Reveals Diverse Virulence-Associated Kinase Targets

Published:2020-12-22 Issue:6 Volume:11 Page:
ISSN:2161-2129
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Shwab E. Keats¹,Juvvadi Praveen R.¹,Waitt Greg²,Shaheen Shareef¹,Allen John¹,Soderblom Erik J.²,Bobay Benjamin G.³⁴⁵,Asfaw Yohannes G.⁶,Moseley M. Arthur²,Steinbach William J.¹⁷

Affiliation:

1. Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA

2. Duke Proteomics Core Facility, Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, USA

3. Duke University NMR Center, Duke University Medical Center, Durham, North Carolina, USA

4. Department of Biochemistry, Duke University, Durham, North Carolina, USA

5. Department of Radiology, Duke University, Durham, North Carolina, USA

6. Department of Laboratory Animal Resources, Duke University Medical Center, Durham, North Carolina, USA

7. Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA

Abstract

PKA is essential for the virulence of eukaryotic human pathogens. Understanding PKA signaling mechanisms is therefore fundamental to deciphering pathogenesis and developing novel therapies.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02880-20

Reference72 articles.

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4. Global regulatory roles of the c AMP/PKA pathway revealed by phenotypic, transcriptomic and phosphoproteomic analyses in a null mutant of the PKA catalytic subunit in C andida albicans

5. Phosphoproteome Analysis Links Protein Phosphorylation to Cellular Remodeling and Metabolic Adaptation during Magnaporthe oryzae Appressorium Development

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