The ESX-1 Substrate PPE68 Has a Key Function in ESX-1-Mediated Secretion in Mycobacterium marinum-Reference-Cited by-同舟云学术

The ESX-1 Substrate PPE68 Has a Key Function in ESX-1-Mediated Secretion in Mycobacterium marinum

Published:2022-12-20 Issue:6 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Damen Merel P. M.¹^ORCID,Meijers Aniek S.²,Keizer Esther M.¹,Piersma Sander R.³,Jiménez Connie R.³,Kuijl Coenraad P.²^ORCID,Bitter Wilbert¹²,Houben Edith N. G.¹^ORCID

Affiliation:

1. Section of Molecular Microbiology, Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

2. Department of Medical Microbiology and Infection Control, Amsterdam UMC, VU Medical Center, Amsterdam, The Netherlands

3. Department of Medical Oncology, OncoProteomics Laboratory, Cancer Center Amsterdam, Amsterdam UMC, VU Medical Center, Amsterdam, The Netherlands

Abstract

Pathogenic mycobacteria, suchMycobacterium tuberculosisandMycobacterium marinum, use a type VII secretion system (T7SS) subtype, called ESX-1, to mediate intracellular survival via phagosomal rupture and subsequent translocation of themycobacteriumto the host cytosol. Identifying the ESX-1 substrate that is responsible for this process is problematic because of the intricate network of codependent secretion between ESX-1 substrates.

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02819-22

Reference80 articles.

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