Comprehensive Analysis of Aspergillus nidulans PKA Phosphorylome Identifies a Novel Mode of CreA Regulation-Reference-Cited by-同舟云学术

Comprehensive Analysis of Aspergillus nidulans PKA Phosphorylome Identifies a Novel Mode of CreA Regulation

Published:2019-04-30 Issue:2 Volume:10 Page:
ISSN:2161-2129
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Ribeiro Liliane F. C.¹,Chelius Cynthia¹,Boppidi Karthik R.¹,Naik Nisha S.¹,Hossain Simin¹,Ramsey Jessica J. J.¹,Kumar Jyothi²,Ribeiro Lucas F.³,Ostermeier Marc³,Tran Bao⁴,Ah Goo Young⁴,de Assis Leandro J.⁵,Ulas Mevlut⁶,Bayram Ozgur⁶,Goldman Gustavo H.⁷⁸^ORCID,Lincoln Stephen⁹,Srivastava Ranjan⁹,Harris Steven D.²,Marten Mark R.¹

Affiliation:

1. Department of Chemical, Biochemical and Environmental Engineering, University of Maryland, Baltimore County (UMBC), Baltimore, Maryland, USA

2. Center for Plant Science Innovation, University of Nebraska, Lincoln, Nebraska, USA

3. Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, USA

4. Mass Spectrometry Center, University of Maryland School of Pharmacy, Baltimore, Maryland, USA

5. Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil

6. Department of Biology, Maynooth University, Maynooth, County Kildare, Ireland

7. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, CEP 14040-903, São Paulo, Brazil

8. Institute for Advanced Study, Technical University of Munich, Garching, Germany

9. Chemical & Biomolecular Engineering Department, University of Connecticut, Storrs, Connecticut, USA

Abstract

The cyclic AMP (cAMP)-dependent protein kinase A (PKA) signaling pathway is well conserved across eukaryotes, and previous work has shown that it plays an important role in regulating development, growth, and virulence in a number of fungi. PKA is activated in response to extracellular nutrients and acts to regulate metabolism and growth. While a number of components in the PKA pathway have been defined in filamentous fungi, current understanding does not provide a global perspective on PKA function. Thus, this work is significant in that it comprehensively identifies proteins and functional pathways regulated by PKA in a model filamentous fungus. This information enhances our understanding of PKA action and may provide information on how to manipulate it for specific purposes.

Funder

National Science Foundation

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02825-18

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