Human IFIT3 Protein Induces Interferon Signaling and Inhibits Adenovirus Immediate Early Gene Expression-Reference-Cited by-同舟云学术

Human IFIT3 Protein Induces Interferon Signaling and Inhibits Adenovirus Immediate Early Gene Expression

Published:2021-12-21 Issue:6 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Chikhalya Aniska¹,Dittmann Meike²^ORCID,Zheng Yueting³,Sohn Sook-Young¹,Rice Charles M.⁴,Hearing Patrick¹

Affiliation:

1. Department of Microbiology & Immunology, Stony Brook University, New York, New York, USA

2. Department of Microbiology, NYU Grossman School of Medicine, New York, New York, USA

3. Synthego Corporation, Menlo Park, California, USA

4. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, New York, USA

Abstract

IFITs belong to a family of IFN-induced proteins that have broad antiviral functions, primarily studied with RNA viruses leaving a gap of knowledge on the effects of these proteins on DNA viruses. In this study we show that IFIT3, with its partner proteins IFIT1 and IFIT2, specifically restricts replication of human Ad, a DNA virus, by stimulating IFNβ production via the STING and MAVS pathways.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02829-21

Reference49 articles.

1. Adenovirus Infections in Immunocompetent and Immunocompromised Patients

2. Adenovirus persistence, reactivation, and clinical management

3. E2F/Rb Family Proteins Mediate Interferon Induced Repression of Adenovirus Immediate Early Transcription to Promote Persistent Viral Infection