Proactive therapeutic monitoring of dalbavancin concentrations in the long-term management of chronic osteoarticular/periprosthetic joint infections-Reference-Cited by-同舟云学术

Proactive therapeutic monitoring of dalbavancin concentrations in the long-term management of chronic osteoarticular/periprosthetic joint infections

Published:2024-04-03 Issue:4 Volume:68 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Cattaneo Dario¹^ORCID,Fusi Marta²,Galli Lucia¹,Genovese Camilla¹,Giorgi Riccardo¹,Matone Maddalena¹,Merli Stefania¹,Colaneri Marta¹^ORCID,Gori Andrea¹²

Affiliation:

1. Department of Infectious Diseases, ASST Fatebenefratelli Sacco University Hospital, Milan, Italy

2. Department of Biomedical and Clinical Sciences, Università degli Studi di Milano, Milan, Italy

Abstract

ABSTRACT Here, we describe the use of proactive therapeutic drug monitoring (TDM) to individualize the optimal timing of drug injections in 16 adult patients with chronic osteoarticular infections receiving a median of 7 injections of dalbavancin (up to 12 injections in 15 months). Dalbavancin injections were repeated at medians of 39–47 days, with infusion intervals ranging from 26 to 69 days. TDM can facilitates a precise, targeted use of dalbavancin for infections requiring prolonged treatments.

Publisher

American Society for Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00023-24

Reference19 articles.

1. Clinical Pharmacokinetics and Pharmacodynamics of Dalbavancin

2. The role of dalbavancin in the treatment of acute bacterial skin and skin structure infections (ABSSSIs)

3. Dalbavancin in Bone and Joint Infections: A Systematic Review

4. Dalbavancin in Gram-positive periprosthetic joint infections

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