Therapeutic efficacy of lanoconazole, a new imidazole antimycotic agent, for experimental cutaneous candidiasis in guinea pigs

Author:

Niwano Y1,Seo A1,Kanai K1,Hamaguchi H1,Uchida K1,Yamaguchi H1

Affiliation:

1. Pharmaceutical Research Institute, Nihon Nohyaku Co., Ltd., Osaka, Japan.

Abstract

The therapeutic efficacy of 1% cream and 1% solution of lanoconazole, a new imidazole antimycotic agent, in the model of cutaneous candidiasis in prednisolone-treated guinea pigs was evaluated in comparison with that of comparable formulations of bifonazole. Each preparation was topically applied once a day for 3 consecutive days, starting on the fifth day postinfection, and quantitative culture study wsa conducted on the ninth day postinfection. Both formulations of lanoconazole were much more highly effective in terms of eradication of fungi than the bifonazole formulations.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference8 articles.

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3. Maebashi K. T. Itoyama K. Uchida and H. Yamaguchi. A novel model of cutaneous candidiasis produced in prednisolone-treated guinea pigs. J. Med. Vet. Mycol. in press.

4. Antifungal activity of the new agent latoconazole in two tinea models;Ohmi T.;Arzneim. Forsch./Drug Res.,1991

5. Inhibitory effect of NND-318 on ergosterol synthesis in Trichophyton mentagrophytes and Candida albicans;Ohmi T.;Jpn. J. Med. Mycol.,1992

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