Early Laboratory Diagnosis of COVID-19 by Antigen Detection in Blood Samples of the SARS-CoV-2 Nucleocapsid Protein-Reference-Cited by-同舟云学术

Early Laboratory Diagnosis of COVID-19 by Antigen Detection in Blood Samples of the SARS-CoV-2 Nucleocapsid Protein

Published:2021-09-20 Issue:10 Volume:59 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Thudium Rebekka F.¹,Stoico Malene P.²,Høgdall Estrid³,Høgh Julie¹,Krarup Henrik B.²⁴,Larsen Margit A. H.⁵,Madsen Poul H.²,Nielsen Susanne D.¹,Ostrowski Sisse R.⁵,Palombini Amanda⁶,Rasmussen Daniel B.¹,Foged Niels T.⁶^ORCID

Affiliation:

1. University of Copenhagen, Rigshospitalet, Department of Infectious Diseases, Copenhagen, Denmark

2. Aalborg University Hospital, Department of Molecular Diagnostics, Aalborg, Denmark

3. Bio- and Genome Bank Denmark, Department of Pathology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, Denmark

4. Aalborg University, Department of Clinical Medicine, Aalborg, Denmark

5. University of Copenhagen, Rigshospitalet, Department of Clinical Immunology, Copenhagen, Denmark

6. Solsten Diagnostics International, Aarhus, Denmark

Abstract

The purpose of this study was to characterize the diagnostic performance of a newly developed enzyme-linked immunosorbent assay (ELISA) for detection of SARS-CoV-2 nucleocapsid protein (NP) in blood. Blood samples were collected during hospitalization of 165 inpatients with PCR-confirmed SARS-CoV-2 infection and from 505 outpatients with relevant symptoms of COVID-19 simultaneously with PCR testing.

Funder

Eureka Network Call for COVID-19

Novo Nordisk Fonden

Rigshospitalet Research Council

Danish Council for Independent Research - Medical Sciences

Innovation Fund Denmark

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01001-21