Affiliation:
1. Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, U. S. Public Health Service, Bethesda, Maryland
Abstract
Hasenclever
, H. F. (U. S. Public Health Service, Bethesda, Md.),
and William O. Mitchell
. Antigenic studies of Candida. III. Comparative pathogenicity of
Candida albicans
group A, group B, and
Candida stellatoidea
. J. Bacteriol.
82:
578–581. 1961.—Since the antigenic differences between
Candida albicans
group A and
C. albicans
group B had been established, the problem of a difference in pathogenicity for laboratory animals was studied.
Candida stellatoidea
was also included in this investigation. Similar experiments with
Candida tropicalis
have been reported.
The virulence of 24 strains of
C. albicans
group A, 23 strains of
C. albicans
group B, and 11 strains of
C. stellatoidea
for mice was determined. Five
C. albicans
group B and four
C. stellatoidea
strains were tested for lethality in rabbits.
C. albicans
group A and
C. albicans
group B displayed about the same degree of virulence for mice. Although
C. stellatoidea
in general showed less virulence for mice than
C. albicans
, some of its strains were more virulent than the least virulent
C. albicans
strains. All five
C. albicans
group B strains tested in rabbits demonstrated considerably more virulence for this laboratory animal than any of the four
C. stellatoidea
strains tested.
C. albicans
group B was isolated from more diverse clinical specimens than
C. albicans
group A, but only a small number of specimens were studied.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
54 articles.
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