Chemoprophylaxis of Shigella flexneri Keratoconjunctivitis in Rabbits

Author:

Cross W. R.1,Nakamura M.1

Affiliation:

1. Department of Microbiology, University of Montana, Missoula, Montana 59801

Abstract

Chloramphenicol, chlortetracycline, streptomycin, and sulfisoxazole prevented keratoconjunctivitis in rabbit eyes infected with Shigella flexneri . The route of administration of the agent and the dose were important variables in controlling the infectious process. This assay system appears to be a useful technique for the in vivo evaluation of chemotherapeutic agents.

Publisher

American Society for Microbiology

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference3 articles.

1. Cornieal ulcer produced by Aerobacter aerogenes;Clark G.;Arch. Ophthalmol.,1951

2. Shigella comeal ulcer;MacDonald R.;Amer. J. Ophthalmol.,1965

3. Vaughan D. R. Cook and T. Asbury. 1968. General ophthalmology. Lange Medical Publications Los Altos Calif

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