Global Epidemiology and Evolutionary History of Staphylococcus aureus ST45-Reference-Cited by-同舟云学术

Global Epidemiology and Evolutionary History of Staphylococcus aureus ST45

Published:2020-12-17 Issue:1 Volume:59 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Effelsberg N.¹,Stegger M.²³^ORCID,Peitzmann L.¹⁴,Altinok O.⁵,Coombs G. W.³,Pichon B.⁶,Kearns A.⁶,Randad P. R.⁷,Heaney C. D.⁷⁸⁹^ORCID,Bletz S.¹,Schaumburg F.¹⁰,Mellmann A.¹^ORCID

Affiliation:

1. Institute of Hygiene, University Hospital Münster, Münster, Germany

2. Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark

3. Antimicrobial Resistance and Infectious Diseases Research Laboratory, Murdoch University, Perth, Western Australia, Australia

4. Genomics and Transcriptomics Laboratory, Heinrich-Heine University, Düsseldorf, Germany

5. Department of Philosophy, Westphalian Wilhelms-University Münster, Münster, Germany

6. Antimicrobial Resistance and Healthcare Associated Infections Reference Unit, National Infection Service, Public Health England, London, United Kingdom

7. Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA

8. Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA

9. Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA

10. Institute of Medical Microbiology, University Hospital Münster, Münster, Germany

Abstract

Staphylococcus aureus ST45 is a major global MRSA lineage with huge strain diversity and a high clinical impact. It is one of the most prevalent carrier lineages but also frequently causes severe invasive disease, such as bacteremia. Little is known about its evolutionary history. In this study, we used whole-genome sequencing to analyze a large collection of 451 diverse ST45 isolates from 6 continents and 26 countries. De novo -assembled genomes were used to understand genomic plasticity and to perform coalescent analyses.

Funder

GRACE Communications Foundation

HHS | NIH | National Institute of Allergy and Infectious Diseases

Deutsche Forschungsgemeinschaft

HHS | NIH | National Institute of Environmental Health Sciences

HHS | CDC | National Institute for Occupational Safety and Health

Bundesministerium für Bildung und Forschung

Thrasher Research Fund

Publisher

American Society for Microbiology

Subject

Microbiology (medical)