Diagnostic Implications of Inconsistent Results Obtained with the Xpert MTB/Rif Assay in Detection of Mycobacterium tuberculosis Isolates with an rpoB Mutation Associated with Low-Level Rifampin Resistance-Reference-Cited by-同舟云学术

Diagnostic Implications of Inconsistent Results Obtained with the Xpert MTB/Rif Assay in Detection of Mycobacterium tuberculosis Isolates with an rpoB Mutation Associated with Low-Level Rifampin Resistance

Published:2013-09 Issue:9 Volume:51 Page:3127-3129
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Somoskovi Akos¹²,Deggim Vanessa¹,Ciardo Diana³,Bloemberg Guido V.¹

Affiliation:

1. Institut für Medizinische Mikrobiologie Universität Zürich, Zürich, Switzerland

2. Nationales Zentrum für Mykobakterien, Universität Zürich, Zürich, Switzerland

3. Viollier AG, Basel, Switzerland

Abstract

ABSTRACT Xpert-MTB/Rif is one of the most frequently used molecular screening tests for multidrug-resistant tuberculosis worldwide. We report false-negative assay results in the presence of rpoB Leu533Pro, which is associated with low-level phenotypic rifampin resistance. Accurate and timely confirmation of rifampin susceptibility results obtained with Xpert-MTB/Rif is imperative.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01377-13

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