Impact of Caveolin-Mediated Endocytosis on the Trafficking of HIV within the Colonic Barrier

Author:

Anwar Alex1,Helou Michelle1,Hervol Jessica1,Levine Alan D.12345ORCID

Affiliation:

1. Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA

2. Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA

3. Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA

4. Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA

5. Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA

Abstract

Despite the success of combination antiretroviral therapy in suppressing HIV replication and the emergence and effectiveness of PrEP-based prevention strategies, in 2018, 37,968 people in the United States received a new HIV diagnosis, accompanied by 15,820 deaths. While the annual number of new diagnoses decreased 7% from 2014 to 2018, 14% of people with HIV did not know they were infected.

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute on Drug Abuse

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference54 articles.

1. Minority HIV/AIDS Fund. 2018. HIV prevention. US Department of Health and Human Services Washington D.C. https://www.hiv.gov/hiv-basics/overview/data-and-trends/statistics.

2. Minority HIV/AIDS Fund. 2019. About ending the HIV epidemic in the U.S. US Department of Health and Human Services Washington D.C. https://www.hiv.gov/federal-response/ending-the-hiv-epidemic/overview.

3. HIV-1 Infection: The Role of the Gastrointestinal Tract

4. Entry of viruses through the epithelial barrier: pathogenic trickery

5. HIV Infection and Gut Mucosal Immune Function: Updates on Pathogenesis with Implications for Management and Intervention

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