Atlastin Endoplasmic Reticulum-Shaping Proteins Facilitate Zika Virus Replication-Reference-Cited by-同舟云学术

Atlastin Endoplasmic Reticulum-Shaping Proteins Facilitate Zika Virus Replication

Published:2019-12 Issue:23 Volume:93 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Monel Blandine¹,Rajah Maaran Michael¹²,Hafirassou Mohamed Lamine³,Sid Ahmed Samy¹,Burlaud-Gaillard Julien⁴,Zhu Peng-Peng⁵,Nevers Quentin¹,Buchrieser Julian¹,Porrot Françoise¹,Meunier Cécile¹,Amraoui Sonia¹,Chazal Maxime⁶,Salles Audrey⁷,Jouvenet Nolwenn⁶,Roingeard Philippe⁴,Blackstone Craig⁵,Amara Ali³,Schwartz Olivier¹^ORCID

Affiliation:

1. Institut Pasteur, Virus and Immunity Unit, CNRS-UMR3569, Paris, France

2. Ecole Doctorale Bio Sorbonne Paris Cité (BioSPC)–Université Paris Diderot, Paris, France

3. Equipe Biologie Cellulaire des Infections Virales, INSERM U944 CNRS 7212, Centre de Recherche Saint-Louis, Paris, France

4. INSERM U1259–Plateforme IBiSA de Microscopie Electronique, Université et CHU de Tours, Tours, France

5. Cell Biology Section, Neurogenetics Branch, National Institutes of Health, Bethesda, Maryland, USA

6. Institut Pasteur, Viral Genomics and Vaccination Unit, Paris, France

7. Institut Pasteur, UtechS Photonic BioImaging PBI (Imagopole), Centre de Recherche et de Resources Technologiques C2RT, Paris, France

Abstract

Zika virus (ZIKV) is an emerging virus associated with Guillain-Barré syndrome, and fetal microcephaly as well as other neurological complications. There is no vaccine or specific antiviral treatment against ZIKV. We found that endoplasmic reticulum (ER)-shaping atlastin proteins (ATL1, -2, and -3), which induce ER membrane fusion, facilitate ZIKV replication. We show that ATL3 is recruited to the viral replication site and colocalize with the viral proteins NS2A and NS2B3. The results provide insights into host factors used by ZIKV to enhance its replication.

Funder

HHS | NIH | National Institute of Neurological Disorders and Stroke

Institut Pasteur

Labex

Agence Nationale de la Recherche

Sidaction

Gilead Foundation

Agence Nationale de Recherches sur le Sida et les Hépatites Virales

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology