Evaluation of Xpert MTB/RIF Ultra Assay for Diagnosis of Childhood Tuberculosis: a Multicenter Accuracy Study

Author:

Sun Lin1,Zhu Yu2,Fang Min3,Shi Yan3,Peng Xiaoshan2,Liao Qiong2,Wang Xingyun1,Quan Shuting1,Wang Yacui1,Duan Li3,Shi Xiaomei3,Zhao Zhipeng1,Chen Lanqin1,Xu Yongsheng4,Zhang Tongqiang4,Cui Xiaojian4,Wan Chaomin2,Shen Adong1ORCID

Affiliation:

1. Beijing Children’s Hospital, Capital Medical University, Beijing, China

2. West China Second Hospital, Sichuan University, Chengdu, Sichuan, China

3. No. 1 People’s Hospital of Liangshan Yizu Autonomous Prefecture, Liangshan, Sichuan, China

4. Tianjin Children’s Hospital, Tianjin, China

Abstract

A multicenter study was performed to evaluate the value of testing gastric aspirate (GA) with Xpert MTB/RIF Ultra assay (Ultra) for childhood tuberculosis (TB) detection in China. In total, 129 children with active TB and 173 children without TB were enrolled. The sensitivity of Ultra in bacteriologically confirmed TB and probable TB cases was 87.5% (42/48) and 44.4% (36/81), respectively. The specificity of Ultra was high (99.4%, 172/173). When Ultra, culture, and acid-fast bacilli outcomes were integrated as a composite reference standard, the percentage of children with definite TB increased from 37.

Funder

MOST | National Science and Technology Planning Project

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference25 articles.

1. World Health Organization. 2019. Global tuberculosis report 2019. World Health Organization, Geneva, Switzerland.

2. Tuberculosis in Infants and Children

3. Role of Streptococcus pneumoniae in Hospitalization for Acute Community-acquired Pneumonia Associated With Culture-confirmed Mycobacterium tuberculosis in Children

4. World Health Organization. 2014. Guidance for national tuberculosis programmes on the management of tuberculosis in children, 2nd ed. World Health Organization, Geneva, Switzerland.

5. Diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculous meningitis in HIV-infected adults: a prospective cohort study

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