Spt20, a Structural Subunit of the SAGA Complex, Regulates Aspergillus fumigatus Biofilm Formation, Asexual Development, and Virulence

Author:

Chen Yuan1,Stewart James I. P.23,Liu Shuai1,Sheppard Donald C.23456,Lu Ling1ORCID,Zhang Shizhu1ORCID

Affiliation:

1. Jiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Microbiology, College of Life Sciences, Nanjing Normal University, Nanjing, China

2. Department of Experimental Medicine, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada

3. Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada

4. Department of Medicine, McGill University, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada

5. Department of Microbiology and Immunology, McGill University, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada

6. McGill Interdisciplinary Initiative in Infection and Immunity (MI4), Montreal, Quebec, Canada

Abstract

Eukaryotic transcription is regulated by a large number of proteins, ranging from sequence-specific DNA-binding factors to transcriptional coactivators (chromatin regulators and the general transcription machinery) and their regulators. Previous research indicated that the sequence-specific complex SomA/PtaB regulates the biofilm formation and asexual development of Aspergillus fumigatus .

Funder

FRQ | Fonds de Recherche du Québec - Santé

Gouvernement du Canada | Canadian Institutes of Health Research

National Natural Science Foundation of China

Priority Academic Program Development of Jiangsu Higher Education Institutions

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

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