The Trypanosome UDP-Glucose Pyrophosphorylase Is Imported by Piggybacking into Glycosomes, Where Unconventional Sugar Nucleotide Synthesis Takes Place-Reference-Cited by-同舟云学术

The Trypanosome UDP-Glucose Pyrophosphorylase Is Imported by Piggybacking into Glycosomes, Where Unconventional Sugar Nucleotide Synthesis Takes Place

Published:2021-05-28 Issue: Volume: Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Villafraz Oriana¹,Baudouin Hélène¹²,Mazet Muriel¹²,Kulyk Hanna³⁴,Dupuy Jean-William⁵,Pineda Erika¹,Botté Cyrille⁶^ORCID,Inaoka Daniel Ken⁷⁸⁹,Portais Jean-Charles³⁴¹⁰¹¹,Bringaud Frédéric¹²^ORCID

Affiliation:

1. Université de Bordeaux CNRS, Microbiologie Fondamentale et Pathogénicité (MFP), UMR 5234, Bordeaux, France

2. Université de Bordeaux CNRS, Centre de Résonance Magnétique des Systèmes Biologiques (CRMSB), UMR 5536, Bordeaux, France

3. Toulouse Biotechnology Institute (TBI), INSA de Toulouse INSA/CNRS 5504, UMR INSA/INRA, Toulouse, France

4. MetaboHUB-MetaToul, National Infrastructure of Metabolomics and Fluxomics, Toulouse, France

5. Université de Bordeaux Plateforme Protéome, Bordeaux, France

6. Apicolipid Team, Institute for Advanced Biosciences, CNRS UMR5309, INSERM U1209, Université Grenoble Alpes, La Tronche, France

7. Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

8. School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan

9. Department of Molecular Infection Dynamics, Shionogi Global Infectious Disease Division, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan

10. RESTORE, Université de Toulouse, INSERM U1031, CNRS 5070, Toulouse, France

11. EFS, Université Paul Sabatier, Toulouse, France

Abstract

Unusual compartmentalization of metabolic pathways within organelles is one of the most enigmatic features of trypanosomatids. These unicellular eukaryotes are the only organisms that sequestered glycolysis inside peroxisomes (glycosomes), although the selective advantage of this compartmentalization is still not clear.

Funder

Bordeaux University

Centre National de la Recherche Scientifique

Agence Nationale de la Recherche

Labex ParaFrap

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00375-21

Reference80 articles.