Extracellular Vesicles Regulate Biofilm Formation and Yeast-to-Hypha Differentiation in Candida albicans-Reference-Cited by-同舟云学术

Extracellular Vesicles Regulate Biofilm Formation and Yeast-to-Hypha Differentiation in Candida albicans

Published:2022-06-28 Issue:3 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Honorato Leandro¹^ORCID,de Araujo Joana Feital Demetrio¹,Ellis Cameron C.²,Piffer Alicia Corbellini¹,Pereira Yan¹,Frases Susana³,de Sousa Araújo Glauber Ribeiro³,Pontes Bruno⁴,Mendes Maria Tays²,Pereira Marcos Dias⁵,Guimarães Allan J.⁶,da Silva Natalia Martins¹,Vargas Gabriele¹,Joffe Luna⁷,Del Poeta Maurizio⁷⁸⁹^ORCID,Nosanchuk Joshua D.¹⁰¹¹,Zamith-Miranda Daniel¹⁰¹¹^ORCID,dos Reis Flávia Coelho Garcia¹²¹³,de Oliveira Haroldo Cesar¹²,Rodrigues Marcio L.¹²¹⁴,de Toledo Martins Sharon¹²,Alves Lysangela Ronalte¹²^ORCID,Almeida Igor C.²^ORCID,Nimrichter Leonardo¹^ORCID

Affiliation:

1. Laboratório de Glicobiologia de Eucariotos, Departamento de Microbiologia Geral, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

2. Department of Biological Sciences, Border Biomedical Research Center, University of Texas at El Paso, El Paso, Texas, USA

3. Laboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofísica Carlos Chagas Filhos (IBCCF), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

4. LPO-COPEA, Instituto de Ciências Biomédicas & Centro Nacional de Biologia Estrutural e Bioimagem (CENABIO), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

5. Laboratório de Citotoxicidade e Genotoxicidade, Departamento de Bioquímica, Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

6. Laboratório de Bioquímica e Imunologia das Micoses, Departamento de Microbiologia e Parasitologia, Instituto Biomédico, Universidade Federal Fluminense, Niterói, Brazil

7. Department of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA

8. Department of Microbiology and Immunology and Division of Infectious Diseases, Stony Brook University, Stony Brook, New York, USA

9. Veterans Affairs Medical Center, Northport, New York, USA

10. Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA

11. Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA

12. Instituto Carlos Chagas (ICC), Fundação Oswaldo Cruz (FIOCRUZ), Curitiba, Brazil

13. Centro de Desenvolvimento Tecnológico em Saúde (CDTS), Fundação Oswaldo Cruz, Rio de Janeiro, Brazil

14. Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

Abstract

The ability to undergo morphological changes during adaptation to distinct environments is exploited by Candida albicans and has a direct impact on biofilm formation and virulence. Morphogenesis is controlled by a diversity of stimuli, including osmotic stress, pH, starvation, presence of serum, and microbial components, among others.

Funder

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação Oswaldo Cruz

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

HHS | National Institutes of Health

Merit Review Grant

HHS | NIH | National Institute on Minority Health and Health Disparities

Publisher

American Society for Microbiology

Subject

Virology,Microbiology