Genetic and Structural Variation in the O-Antigen of Salmonella enterica Serovar Typhimurium Isolates Causing Bloodstream Infections in the Democratic Republic of the Congo

Author:

Van Puyvelde Sandra1234ORCID,Gasperini Gianmarco5,Biggel Michael2ORCID,Phoba Marie-France67,Raso Maria Michelina5ORCID,de Block Tessa4,Vanheer Leen N.4,Deborggraeve Stijn4,Vandenberg Olivier8910,Thomson Nicholas311,Ravenscroft Neil12,Maclennan Calman A.13,Bellich Barbara14,Cescutti Paola14,Dougan Gordon1,Jacobs Jan415,Lunguya Octavie67,Micoli Francesca5

Affiliation:

1. Cambridge Institute of Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, United Kingdom

2. Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium

3. Wellcome Trust Sanger Institute, Hinxton, United Kingdom

4. Institute of Tropical Medicine, Antwerp, Belgium

5. GSK Vaccines Institute for Global Health, Siena, Italy

6. Department of Microbiology, Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo

7. Department of Medical Biology, University Teaching Hospital of Kinshasa, Kinshasa, Democratic Republic of the Congo

8. Clinical Research and Innovation Unit, Laboratoire Hospitalier Universitaire de Bruxelles-Universitair Laboratorium Brussel, Université Libre de Bruxelles, Brussels, Belgium

9. Centre for Environmental Health and Occupational Health, School of Public Health, Université Libre de Bruxelles, Brussels, Belgium

10. Division of Infection and Immunity, Faculty of Medical Sciences, University College London, London, United Kingdom

11. London School of Hygiene and Tropical Medicine, London, United Kingdom

12. Department of Chemistry, University of Cape Town, Rondebosch, South Africa

13. Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

14. Department of Life Sciences, University of Trieste, Trieste, Italy

15. Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium

Abstract

The bacterium Salmonella Typhimurium forms a devastating burden in sub-Saharan Africa by causing invasive bloodstream infections. Additionally, Salmonella Typhimurium presents high levels of antimicrobial resistance, jeopardizing treatment.

Funder

BactiVac

Bill and Melinda Gates Foundation

National Institute for Health Research

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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