Discovery and Characterization of Pneumococcal Serogroup 36 Capsule Subtypes, Serotypes 36A and 36B

Author:

Ganaie Feroze A.1ORCID,Saad Jamil S.2,Lo Stephanie W.3ORCID,McGee Lesley4,Bentley Stephen D.3,van Tonder Andries J.5,Hawkins Paulina6,Keenan Jeremy D.7,Calix Juan J.18,Nahm Moon H.1ORCID

Affiliation:

1. Department of Medicine, Division of Pulmonary/Allergy/Critical Care, University of Alabama at Birmingham, Birmingham, Alabama, USA

2. Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA

3. Parasites and Microbes, Wellcome Sanger Institute, Hinxton, Cambridge, United Kingdom

4. Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

5. Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom

6. Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA

7. Department of Ophthalmology, University of California, San Francisco, California, USA

8. Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, USA

Abstract

Streptococcus pneumoniae can produce a wide breadth of antigenically diverse capsule types, a fact that poses a looming threat to the success of vaccines that target pneumococcal polysaccharide (PS) capsule. Yet, many pneumococcal capsule types remain undiscovered and/or uncharacterized.

Funder

Bill and Melinda Gates Foundation

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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