Serum Complement Sensitivity as a Key Factor in Lyme Disease Ecology

Author:

Kurtenbach Klaus12,Sewell Henna-Sisko12,Ogden Nick H.3,Randolph Sarah E.1,Nuttall Patricia A.2

Affiliation:

1. Department of Zoology, University of Oxford, Oxford OX1 3PS,1

2. NERC Institute of Virology and Environmental Microbiology, Oxford OX1 3SR,2 and

3. Department of Veterinary Clinical Medicine, Faculty of Veterinary Science, University of Liverpool, Liverpool L69 3BX,3 United Kingdom

Abstract

ABSTRACT The sensitivity of Borrelia burgdorferi sensu lato to animal sera was analyzed. Complement-mediated borreliacidal effects were observed with particular combinations of host serum and Borrelia genospecies. The species-specific pattern of viability and/or lysis is highly consistent with the pattern of reservoir competence of hosts for B. burgdorferi sensu lato, suggesting a key role of complement in the global ecology of Lyme borreliosis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference31 articles.

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2. Role of grey squirrels and pheasants in the transmission of Borrelia burgdorferi sensu lato, the Lyme disease spirochaete, in the UK.;Craine N. G.;Folia Parasitol.,1997

3. Simultaneous presence of different Borrelia burgdorferi genospecies in biological fluids of Lyme disease patients

4. Borrelia burgdorferi genes selectively expressed in ticks and mammals.;De Silva A. M.;Parasitol. Today,1997

5. Small mammals as reservoir hosts for Borrelia in Russia.;Gorelova B. N.;Zentralbl. Bakteriol.,1995

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