Affiliation:
1. Department of Physiological Sciences, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom
Abstract
ABSTRACT
Quantitative analysis of
Yersinia pseudotuberculosis
infection of murine gut loops revealed that significantly more wild-type bacteria associated with Peyer’s patch M cells than with dome enterocytes or goblet cells. An invasin-deficient mutant was significantly attenuated for M-cell invasion, while β1 integrin expression was demonstrated in the apical membranes of M cells but not enterocytes. M-cell targeting by
Yersinia pseudotuberculosis
in vivo may, therefore, be mediated primarily by the interaction of invasin with cell surface β1 integrins.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
317 articles.
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