Efflux Pump Overexpression in Multiple-Antibiotic-Resistant Mutants of Bacteroides fragilis-Reference-Cited by-同舟云学术

Efflux Pump Overexpression in Multiple-Antibiotic-Resistant Mutants of Bacteroides fragilis

Published:2006-09 Issue:9 Volume:50 Page:3150-3153
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Pumbwe Lilian¹²,Glass Daniel²,Wexler Hannah M.¹²

Affiliation:

1. Greater Los Angeles Veterans Administration Healthcare Systems

2. Department of Medicine, University of California, Los Angeles, Los Angeles, California

Abstract

ABSTRACT Multidrug-resistant mutants of a wild-type Bacteroides fragilis strain (strain ADB77) and a quadruple resistance nodulation division family efflux pump deletion mutant (ADB77 Δ bmeB1 Δ bmeB3 Δ bmeB12 Δ bmeB15 ) were selected with antimicrobials. Ampicillin, doripenem, imipenem, levofloxacin, and metronidazole selected for mutants from both strains; cefoxitin selected for mutants from strain ADB77 only; and sodium dodecyl sulfate selected mutants from ADB77Δ bmeB1 Δ bmeB3 Δ bmeB12 Δ bmeB15 only. The mutants overexpressed one or more efflux pumps.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00141-06

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