Transferable Resistance Gene optrA in Enterococcus faecalis from Swine in Brazil-Reference-Cited by-同舟云学术

Transferable Resistance Gene optrA in Enterococcus faecalis from Swine in Brazil

Published:2020-05-21 Issue:6 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Almeida Lara M.¹²^ORCID,Lebreton François³,Gaca Anthony³,Bispo Paulo M.³,Saavedra Jose T.³,Calumby Rodrigo N.²,Grillo Luciano M.²^ORCID,Nascimento Ticiano G.²^ORCID,Filsner Pedro H.⁴,Moreno Andrea M.⁴^ORCID,Gilmore Michael S.³

Affiliation:

1. Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo, SP, Brazil

2. Institute of Pharmaceutical Sciences, Federal University of Alagoas, Maceió, Alagoas, Brazil

3. Department of Ophthalmology and Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA

4. School of Veterinary Medicine and Animal Science, University of São Paulo, SP, Brazil

Abstract

OptrA is an ATP-binding cassette (ABC)-F protein that confers resistance to oxazolidinones and phenicols and can be either plasmid-encoded or chromosomally encoded. Here, we isolated 13 Enterococcus faecalis strains possessing a linezolid MIC of ≥4 mg/liter from nursery pigs in swine herds located across Brazil. Genome sequence comparison showed that these strains possess optrA in different genetic contexts occurring in 5 different E. faecalis sequence type backgrounds.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00142-20

Reference50 articles.

1. Antibiotic Resistance ABC-F Proteins: Bringing Target Protection into the Limelight

2. A novel gene, optrA, that confers transferable resistance to oxazolidinones and phenicols and its presence in Enterococcus faecalis and Enterococcus faecium of human and animal origin

3. Genetic environment of the transferable oxazolidinone/phenicol resistance geneoptrAinEnterococcus faecalisisolates of human and animal origin

4. Nationwide Surveillance of Novel Oxazolidinone Resistance Gene optrA in Enterococcus Isolates in China from 2004 to 2014

5. Tn6674 Is a Novel Enterococcal optrA-Carrying Multiresistance Transposon of the Tn554 Family

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