Capsid Region Involved in Hepatitis A Virus Binding to Glycophorin A of the Erythrocyte Membrane-Reference-Cited by-同舟云学术

Capsid Region Involved in Hepatitis A Virus Binding to Glycophorin A of the Erythrocyte Membrane

Published:2004-09-15 Issue:18 Volume:78 Page:9807-9813
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Sánchez Glòria¹,Aragonès Lluís¹,Costafreda M. Isabel¹,Ribes Enric²,Bosch Albert¹,Pintó Rosa M.¹

Affiliation:

1. Virus Entèrics, Department of Microbiology

2. Department of Cell Biology, University of Barcelona, Barcelona, Spain

Abstract

ABSTRACT Hepatitis A virus (HAV) has previously been reported to agglutinate human red blood cells at acidic pHs. Treatment of erythrocytes with different enzymes and chemical reagents indicated that HAV attachment is mediated through an interaction with sialylglycoproteins. HAV hemagglutination could be blocked by incubating the virus with glycophorin A, indicating that this sialylglycoprotein is the erythrocyte receptor. The number of receptors used was estimated to be around 500 per cell. At the same time, HAV-induced hemagglutination could also be blocked by either monoclonal antibody H7C27 or an anti-VP3(102-121) ascitic fluid, indicating that lysine 221 of VP1 and the surrounding VP3 residues lining the capsid pit are involved in HAV binding to erythrocytes.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.78.18.9807-9813.2004

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