Affiliation:
1. Department of Microbiology and Immunology, Dartmouth Medical School, and the Norris Cotton Cancer Center, Lebanon, New Hampshire 03756
Abstract
ABSTRACT
LP-BM5 retrovirus-infected C57BL/6 mice develop splenomegaly, lymphadenopathy, hypergammaglobulinemia, and immunodeficiency; thus, this disease has been named mouse AIDS. In this syndrome, CD154/CD40 interactions are required for but do not mediate disease by upregulation of CD80 or CD86. We report here that there is nonetheless a necessity for CD40 signaling competence, specifically an intact tumor necrosis factor receptor-associated factor 6 (TRAF 6) binding site.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology