Engagement of ICAM-3 Provides a Costimulatory Signal for Human Immunodeficiency Virus Type 1 Replication in both Activated and Quiescent CD4 + T Lymphocytes: Implications for Virus Pathogenesis-Reference-Cited by-同舟云学术

Engagement of ICAM-3 Provides a Costimulatory Signal for Human Immunodeficiency Virus Type 1 Replication in both Activated and Quiescent CD4 + T Lymphocytes: Implications for Virus Pathogenesis

Published:2004-06-15 Issue:12 Volume:78 Page:6692-6697
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Barat Corinne¹,Gervais Philippe¹,Tremblay Michel J.¹

Affiliation:

1. Research Center in Infectious Diseases, CHUL Research Center, and Faculty of Medicine, Laval University, Quebec, Canada

Abstract

ABSTRACT Human immunodeficiency virus type 1 (HIV-1) replication is regulated by several extracellular signals. We demonstrate that intercellular adhesion molecule 3 (ICAM-3) acts as a costimulating molecule to increase HIV-1 transcription and viral production, a process allowing productive infection of quiescent CD4 + T lymphocytes. The present work suggests an important role for ICAM-3 in HIV-1 replication.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.78.12.6692-6697.2004

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