Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus-Reference-Cited by-全球学者库

Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus

Published:2016-03-15 Issue:6 Volume:90 Page:3253-3256
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Yang Xing-Lou¹,Hu Ben¹,Wang Bo¹,Wang Mei-Niang¹,Zhang Qian¹,Zhang Wei¹,Wu Li-Jun¹,Ge Xing-Yi¹,Zhang Yun-Zhi²,Daszak Peter³,Wang Lin-Fa⁴,Shi Zheng-Li¹^ORCID

Affiliation:

1. Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China

2. Yunnan Institute of Endemic Diseases Control and Prevention, Dali, China

3. EcoHealth Alliance, New York, New York, USA

4. Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore, Singapore

Abstract

ABSTRACT We report the isolation and characterization of a novel bat coronavirus which is much closer to the severe acute respiratory syndrome coronavirus (SARS-CoV) in genomic sequence than others previously reported, particularly in its S gene. Cell entry and susceptibility studies indicated that this virus can use ACE2 as a receptor and infect animal and human cell lines. Our results provide further evidence of the bat origin of the SARS-CoV and highlight the likelihood of future bat coronavirus emergence in humans.

Funder

National Natural Science Foundation of China

Minister of Science and Technology of the People's Republic of China

HHS | National Institutes of Health

National Research Foundation Singapore

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02582-15

Reference15 articles.